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OriGene
TP53RK Monoclonal Antibody (OTI5G7), TrueMAB™
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产品信息
CF808230
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI5G7
抗原
Full length human recombinant protein of human TP53RK produced in E.coli.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Atypical serine/threonine protein kinase TP53RK; EKC/KEOPS complex subunit TP53RK; Nori-2; p53-related protein kinase; TP53 regulating kinase; TP53-regulating kinase; Trp53 regulating kinase
基因别名: 2810408M09Rik; 4933401B08Rik; 5630401H01Rik; BUD32; C20orf64; dJ101A2; mNori-2p; Nori-2; Nori-2p; PRPK; TP53RK; Trp53rk; Trp53tk
UniProt ID: (Human) Q96S44
Entrez Gene ID: (Human) 112858, (Rat) 362272, (Mouse) 76367
