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Invitrogen
TPCN2 (extracellular) Polyclonal Antibody
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TPCN2 (extracellular) Antibody (PA5-77336) in IHC
Immunohistochemistry analysis of TPCN2 (extracellular) in rat cerebellum. A) Samples were probed with TPCN2 (extracellular) polyclonal antibody (Product # PA5-77336) (green) and incubated with DAPI. B) The extent of the granule layer and image of the DAPI counterstain.
产品信息
PA5-77336
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide KKTLKSIRW(S)LPE(C), corresponding to amino acid residues 187-199 of mouse Two pore calcium channel protein 2 with replacement of amino acid 192 with serine (S)
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
靶标信息
Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Tpcn2 may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The Tpcn2 protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. Tpcn2 is a ubiquitously expressed gene that has elevated expression in liver and kidney. Two common nonsynonymous SNPs in the Tpcn2 gene strongly associate with blond versus brown hair pigmentation. Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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