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Agrisera
TPL/Transcription factor TOPLESS Polyclonal Antibody
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TPL/Transcription factor TOPLESS Antibody (AS16-3207) in WB
20 µg of total protein from Arabidopsis thaliana Col-0 (wt) (1), Zea mays leaf total protein extract (2), tpl/tpr 1/tpr 4 triple mutant in Col-0 background (3), Tpl mutant (N 655127) (4), extracted with 1 x LDS loading buffer to 50 mg tissue powder and proteins were denatured at 75°C for 10 min (1 x LDS buffer: 10% glycerol, 250 m M Tris-HCl p H 8.5,0.5 m M EDTA, 2% Lithium dodecyl sulfate, 0.005% Bromophen... View More
产品信息
AS16-3207
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide derived from Arabidopsis thaliana TPL sequence.
偶联物
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
TPL, also called TOPLESS, is a plant transcriptional co repressor that binds EAR motif containing repressors and bridges them to chromatin remodeling machinery to silence target genes. It partners with proteins such as AUX IAA, JAZ, and NINJA to modulate auxin and jasmonate signaling, and with other transcription factors to shape embryogenesis, meristem function, and organ patterning. TPL recruits histone deacetylases and other chromatin modifiers, tightening nucleosome packing and reducing transcription at specific loci. Multiple TPL and TPL related proteins provide redundancy and specificity across tissues and developmental stages. Perturbation of TPL alters hormone sensitivity, growth, and stress responses by shifting the balance of activation and repression in key regulatory networks.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT1G15750; F7H2.9; F7H2_9; TOPLESS; WSIP1; WUS-INTERACTING PROTEIN 1
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