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Proteintech
TPP1 Polyclonal Antibody
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产品信息
12479-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TPP1 Fusion Protein Ag3173 (215-563 aa encoded by BC014863)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: DVGSGTSNN SQACAQFLEQ YFHDSDLAQF MRLFGGNFAH QASVARVVGQ QGRGRAGIEA SLDVQYLMSA GANISTWVYS SPGRHEGQEP FLQWLMLLSN ESALPHVHTV SYGDDEDSLS SAYIQRVNTE LMKAAARGLT LLFASGDSGA GCWSVSGRHE FRPTFPASSP YVTTVGGTSF QEPFLITNEI VDYISGGGFS NVFPRPSYQE EAVTKFLSSS PHLPPSSYFN ASGRAYPDVA ALSDGYWVVS NRVPIPWVSG TSASTPVFGG ILSLINEHRI LSGRPPLGFL NPRLYQQHGA GLFDVTRGCH ESCLDEEVEG QGFCSGPGWD PVTGWGTPNF PALLKTLLNP (215-563 aa encoded by BC014863)
靶标信息
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cell growth-inhibiting gene 1 protein; ceroid-lipofuscinosis, neuronal 2; CLN 2; GIG 1; growth-inhibiting protein 1; LPIC; lysosomal pepstatin insensitive protease; Lysosomal pepstatin-insensitive protease; MGC21297; TPP 1; TPP I; TPP-1; TPP-I; TPPI; Tripeptidyl aminopeptidase; tripeptidyl peptidase I; tripeptidyl peptidase-I; Tripeptidyl-peptidase 1; Tripeptidyl-peptidase I
基因别名: CLN2; GIG1; LPIC; SCAR7; TPP-1; TPP-I; TPP1; UNQ267/PRO304
UniProt ID: (Human) O14773, (Mouse) O89023, (Rat) Q9EQV6
Entrez Gene ID: (Human) 1200, (Mouse) 12751, (Rat) 83534
proteolysis
lipid metabolic process
lysosome organization
nervous system development
central nervous system development
protein catabolic process
epithelial cell differentiation
IRE1-mediated unfolded protein response
peptide catabolic process
bone resorption
neuromuscular process controlling balance
