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Proteintech
TRADD Polyclonal Antibody
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产品信息
15468-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TRADD Fusion Protein Ag7768 (1-312 aa encoded by BC004491)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAAGQNGHE EWVGSAYLFV ESSLDKVVLS DAYAHPQQKV AVYRALQAAL AESGGSPDVL QMLKIHRSDP QLIVQLRFCG RQPCGRFLRA YREGALRAAL QRSLAAALAQ HSVPLQLELR AGAERLDALL ADEERCLSCI LAQQPDRLRD EELAELEDAL RNLKCGSGAR GGDGEVASAP LQPPVPSLSE VKPPPPPPPA QTFLFQGQPV VNRPLSLKDQ QTFARSVGLK WRKVGRSLQR GCRALRDPAL DSLAYEYERE GLYEQAFQLL RRFVQAEGRR ATLQRLVEAL EENELTSLAE DLLGLTDPNG GLA (1-312 aa encoded by BC004491)
靶标信息
TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is an important mediator of FAS and TNFR1 associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD acts by interacting with TRIP12 and leading to the disruption of the interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. TRADD acts as an adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interation with FADD. Overexpression of TRADD leads to two major TNF-induced responses - apoptosis and activation of NF-kappa-B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Hs89862; MGC11078; TNF receptor 1 associated signal transducer; TNFR1-associated DEATH domain protein; TNFRSF1A-associated via death domain; tradd; tumor necrosis factor receptor type 1 associated death domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
基因别名: 9130005N23Rik; AA930854; Hs.89862; TRADD
UniProt ID: (Human) Q15628, (Mouse) Q3U0V2
Entrez Gene ID: (Human) 8717, (Mouse) 71609
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
extrinsic apoptotic signaling pathway via death domain receptors
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
tumor necrosis factor-mediated signaling pathway
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
positive regulation of hair follicle development
death-inducing signaling complex assembly
extrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of apoptotic process
