Invitrogen

TRAF2 Recombinant Rabbit Monoclonal Antibody (12H7L9)

高级验证

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.

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产品信息

702256

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:250-1:1000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Monoclonal

类型

Antibody

克隆号

12H7L9

抗原

Peptides corresponding to Human TRAF2 (aa 483-501, 37-53)
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偶联物

Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2633073

产品详细信息

This antibody is predicted to react with Monkey, Horse, Rat and Pig

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: E3 ubiquitin-protein ligase TRAF2; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TNF receptor-associated factor 2; tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3

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基因别名: AI325259; MGC:45012; TRAF2; TRAP; TRAP3

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UniProt ID: (Human) Q12933, (Mouse) P39429

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Entrez Gene ID: (Human) 7186, (Mouse) 22030, (Rat) 311786

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功能
ubiquitin-protein transferase activity signal transducer activity tumor necrosis factor receptor binding CD40 receptor binding protein binding zinc ion binding ligase activity enzyme binding protein kinase binding protein phosphatase binding mitogen-activated protein kinase kinase kinase binding ubiquitin protein ligase binding thioesterase binding protein complex binding identical protein binding sphingolipid binding receptor binding lipid binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity scaffold/adaptor protein
参与通路
positive regulation of T cell cytokine production protein complex assembly activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction I-kappaB kinase/NF-kappaB signaling activation of NF-kappaB-inducing kinase activity regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death protein catabolic process positive regulation of interleukin-2 production tumor necrosis factor-mediated signaling pathway negative regulation of glial cell apoptotic process response to endoplasmic reticulum stress regulation of apoptotic process positive regulation of JUN kinase activity cellular protein complex assembly positive regulation of T cell activation regulation of immunoglobulin secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein heterooligomerization protein autoubiquitination intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress protein homotrimerization protein K63-linked ubiquitination death-inducing signaling complex assembly cellular response to nitric oxide positive regulation of protein homodimerization activity activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway programmed necrotic cell death negative regulation of neuron death regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of I-kappaB phosphorylation positive regulation of extrinsic apoptotic signaling pathway apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of JNK cascade
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