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Invitrogen
TRAF3 Isoform 2 Monoclonal Antibody (433113)
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产品信息
MA5-61287
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
433113
抗原
E. coli-derived recombinant human TRAF-3, Met1-Pro543
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
TRAF3 Isoform 2 is a variant of the TNF receptor-associated factor 3 (TRAF3) gene, which plays a crucial role in the regulation of immune responses, inflammation, and cell survival. TRAF3 is a part of the TRAF protein family, which mediates signal transduction from various receptors of the TNF receptor superfamily, Toll-like receptors (TLRs), and other immune receptors. Isoform 2 of TRAF3 may have distinct regulatory functions compared to the canonical form, potentially influencing specific signaling pathways. TRAF3 is known to act as a negative regulator of the non-canonical NF-kappaB signaling pathway, which is important for immune homeostasis and prevention of chronic inflammation. Alterations or mutations in TRAF3, including its isoforms, have been associated with various diseases, including autoimmune disorders, lymphomas, and other cancers. Research into TRAF3 Isoform 2 could provide insights into its unique roles and therapeutic potential in modulating immune responses and treating related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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