FIGURE: 1 / 1
Peptide sequence: GPAFSAVTTI TKADGTSTYK QHCRTPSSSS TLAYSPRDEE DSMPPISTPR
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rat: 100%
TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.
Protein Aliases: DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; MGC7807; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; TNF receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase
Gene Aliases: RFWD1; RNF119; TRAF7
UniProt ID: (Human) Q6Q0C0
Entrez Gene ID: (Human) 84231