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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • TRAF7 Antibodies

          Invitrogen

          TRAF7 Polyclonal Antibody

          View all (4) TRAF7 antibodies
          Datasheet
          Protocols
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          Cite TRAF7 Polyclonal Antibody

          Datasheet
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          • Antibody Testing Data (1)
          TRAF7 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          TRAF7 Antibody (PA5-42346) in WB

          Western blot analysis of human stomach cells using an anti-TRAF7 polyclonal antibody (Product # PA5-42346). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Product Details

          PA5-42346

          Applications
          Tested Dilution
          Publications

          免疫印迹 (WB)

          0.2-1 µg/mL
          -
          产品规格

          Species Reactivity

          Human

          Host/Isotype

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          Immunogen

          Synthetic peptide directed towards the N-terminal of human TRAF7
          View immunogen

          Conjugate

          Unconjugated

          形式

          Liquid

          浓度

          0.5 mg/mL

          纯化类型

          Affinity Chromatography

          保存液

          PBS with 2% sucrose

          内含物

          0.09% sodium azide

          保存条件

          -20° C, Avoid Freeze/Thaw Cycles

          RRID

          AB_2607222

          Product Specific Information

          Peptide sequence: GPAFSAVTTI TKADGTSTYK QHCRTPSSSS TLAYSPRDEE DSMPPISTPR

          Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rat: 100%

          Target Information

          TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; MGC7807; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; TNF receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase

          View more View less

          Gene Aliases: RFWD1; RNF119; TRAF7

          View more View less

          UniProt ID: (Human) Q6Q0C0

          View more View less

          Entrez Gene ID: (Human) 84231

          View more View less

          Function(s)
          activation of MAPKKK activity transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process protein ubiquitination positive regulation of MAPK cascade positive regulation of apoptotic signaling pathway
          Process(es)
          ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity
          It has to be done as per old AB suggested Products section.
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          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
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          We're here to help

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