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Invitrogen
TRAF7 Polyclonal Antibody
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产品信息
PA5-59490
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human TRAF7
偶联物
形式
Liquid
浓度
0.05 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: VWDTCTTYKC QKTLEGHDGI VLALCIQGCK LYSGSADCTI IVWDIQNLQK VNTIRAHDNP VCTLVSSHNV LFSGSLKAIK VWDIVGTELK LKKELTGLNH WVR
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
靶标信息
TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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