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TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: RISC-loading complex subunit TARBP2; TAR (HIV) RNA binding protein 2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; TAR (HIV-1) RNA binding protein 2; TAR RNA binding protein 2; TAR RNA-binding protein 2; TARBP2; TARBP2, RISC loading complex RNA binding subunit; trans-activation responsive RNA-binding protein; Trans-activation-responsive RNA-binding protein
基因别名: LOQS; TARBP2; TRBP; TRBP1; TRBP2
UniProt ID: (Human) Q15633
Entrez Gene ID: (Human) 6895, (Horse) 100062193
