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Invitrogen
TRF2 Polyclonal Antibody
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TRF2 Antibody (PA5-19426) in ICC/IF
Immunofluorescence analysis of TRF2 was performed using 70% confluent log phase MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with TRF2 Polyclonal Antibody (Product # PA5-19426) at 5 microgram/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488 conjugate (Produ... View More
产品信息
PA5-19426
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from residues 250 - 350 of Human TRF2.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA5-19426 targets TRF2 in IF and WB applications and shows reactivity with Human samples.
The PA5-19426 immunogen is synthetic peptide derived from residues 250 - 350 of Human TRF2.
PA5-19426 detects TRF2 which has a predicted molecular weight of approximately 65 kDa and 69 kDa.
Store antibody at 4°C for 1-2 weeks. For long-term storage, store at -20°C.
靶标信息
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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