Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
TRIB3 Monoclonal Antibody (2C10C7)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
66702-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2C10C7
抗原
TRIB3 Fusion Protein Ag25776 (1-358 aa encoded by BC027484)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MRATPLAAP AGSLSRKKRL ELDDNLDTER PVQKRARSGP QPRLPPCLLP LSPPTAPDRA TAVATASRLG PYVLLEPEEG GRAYRALHCP TGTEYTCKVY PVQEALAVLE PYARLPPHKH VARPTEVLAG TQLLYAFFTR THGDMHSLVR SRHRIPEPEA AVLFRQMATA LAHCHQHGLV LRDLKLCRFV FADRERKKLV LENLEDSCVL TGPDDSLWDK HACPAYVGPE ILSSRASYSG KAADVWSLGV ALFTMLAGHY PFQDSEPVLL FGKIRRGAYA LPAGLSAPAR CLVRCLLRRE PAERLTATGI LLHPWLRQDP MPLAPTRSHL WEAAQVVPDG LGLDEAREEE GDREVVLYG (1-358 aa encoded by BC027484 )
靶标信息
A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DJ1103G7.3; induced in fatty liver dystrophy 2; kinase; Neuronal cell death Inducible Putative Kinase; Neuronal cell death-inducible putative kinase; p65-interacting inhibitor of NF-kappa-B; p65-interacting inhibitor of NF-kappaB; SINK; TRB-3; Tribbles 3; Tribbles homolog 3
基因别名: C20orf97; Ifld2; NIPK; SINK; SKIP3; TRB-3; TRB3; TRIB3
UniProt ID: (Human) Q96RU7, (Mouse) Q8K4K2, (Rat) Q9WTQ6
Entrez Gene ID: (Human) 57761, (Mouse) 228775, (Rat) 246273
transcription corepressor activity
protein kinase inhibitor activity
protein binding
ATP binding
kinase activity
protein kinase binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity
protein kinase activity
transferase activity, transferring phosphorus-containing groups
enzyme binding
non-receptor serine/threonine protein kinase
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
protein phosphorylation
negative regulation of protein kinase activity
regulation of glucose transport
positive regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
response to endoplasmic reticulum stress
regulation of MAP kinase activity
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of ubiquitin-protein transferase activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of transcription, DNA-templated
apoptotic process
positive regulation of protein catabolic process
negative regulation of nucleic acid-templated transcription
programmed cell death
