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Invitrogen
TROP2 Recombinant Rabbit Monoclonal Antibody (30)
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产品信息
MA5-52210
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
30
抗原
Recombinant Human TROP2 protein (His 27-Thr274)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Cross-reactivity in ELISA with Human TROP2/TACSTD2 Protein, Human TROP2/TACSTD2 Protein, Rhesus/Cynomolgus TROP2 Protein. No cross-reactivity in ELISA with Human BCAM/CD239, Human VCAM1/CD106, Human ICAM1/CD54, Human CD146/MCAM/MUC18, Human CD171/NCAML1/L1CAM, Human Cadherin-1/E-cadherin/CDH1/CD324, Mouse TROP2/TACSTD2 Protein, and Rat TROP-2/TACSTD2 Protein.
Cross-reactivity in IHC with Rhesus/Cynomolgus. No cross-reactivity in IHC with Mouse and Rat.
靶标信息
TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 40kD glycoprotein, identified by monoclonal antibody GA733; Cell surface glycoprotein Trop-2; cell surface glycoprotein TROP2; epithelial glycoprotein-1; GA733; gastrointestinal tumor-associated antigen GA7331; Membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; Pancreatic carcinoma marker protein GA733-1; pancreatic carcinoma marker protein GA7331; TACD2; truncated TACSTD2; Tumor-associated calcium signal transducer 2
基因别名: EGP-1; EGP1; GA733-1; GA7331; GP50; M1S1; TACSTD2; TROP2
UniProt ID: (Human) P09758
Entrez Gene ID: (Human) 4070
cell surface receptor signaling pathway
visual perception
cell proliferation
negative regulation of epithelial cell migration
regulation of epithelial cell proliferation
negative regulation of stress fiber assembly
ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
cell-cell adhesion
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of ruffle assembly
negative regulation of cell motility
positive regulation of stem cell differentiation
