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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • TRPC4 Antibodies

          Invitrogen

          TRPC4 Polyclonal Antibody

          View all (5) TRPC4 antibodies
          Datasheet
          Protocols
          Tech Support

          Cite TRPC4 Polyclonal Antibody

          Datasheet
          Protocols
          Tech Support
          • Antibody Testing Data (1)
          TRPC4 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          TRPC4 Antibody (PA5-95508) in WB

          Western blot analysis of TRPC4 in Lane 1: human HeLa whole cell lysates, Lane 2: human COLO-320 whole cell lysates, Lane 3: human MCF-7 whole cell lysates, Lane 4: human 293T whole cell lysates. Electrophoresis was performed with 5-20% SDS-PAGE gel (70V, Stacking gel; 90V Resolving gel, Time: 2-3 hours), transferred to a nitrocellulose membrane and blocked using 5% Non-fat Milk/TBS (1.5 hrs at room temperature). Samples were incubated with TRPC4 polyclonal antibody (Product # PA5-95508) using a 0.5 µg/mL dilution, followed by a goat anti-r... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Product Details

          PA5-95508

          Applications
          Tested Dilution
          Publications

          免疫印迹 (WB)

          0.1-0.5 µg/mL
          -
          产品规格

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          Immunogen

          A synthetic peptide corresponding to a sequence of human TRPC4 (MAQFYYKRNVNAPYRDRIPLRIVRAESEL).
          View immunogen

          Conjugate

          Unconjugated

          形式

          Lyophilized

          浓度

          500 µg/mL

          纯化类型

          Affinity chromatography

          保存液

          PBS with 4mg trehalose

          内含物

          0.05mg sodium azide

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          RRID

          AB_2807310

          Product Specific Information

          Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

          Target Information

          TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. TRPC4 forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4. The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7). Diseases associated with TRPC4 include Photosensitive Epilepsy.CaV3.3 encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by CaV3.3 is characterized by a slower activation and inactivation compared to other T-type calcium channels. CaV3.3 may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants of CaV3.3. Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization, an proteins such as CaV3.3 regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Diseases associated with CACNA1I include Childhood Absence Epilepsy.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: alpha TRPC4; beta TRPC4; beta-2 TRPC4; capacitative calcium entry channel 1; Capacitative calcium entry channel Trp4; CCE1; hTrp-4; MGC119570; MGC119571; MGC119572; MGC119573; putative capacitative calcium entry channel; Receptor-activated cation channel TRP4; Short transient receptor potential channel 4; transient receptor potential cation channel, subfamily C, member 4; transient receptor potential channel 4; transient receptor potential protein 4; transient receptor protein 4; Trp-related protein 4; TRPC 4; TrpC4; Trpc4_v2

          View more View less

          Gene Aliases: CCE1; HTRP-4; HTRP4; STRPC4; TRP4; TRPC4; Trrp4

          View more View less

          UniProt ID: (Human) Q9UBN4, (Mouse) Q9QUQ5

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          Entrez Gene ID: (Human) 7223, (Rat) 84494, (Mouse) 22066

          View more View less

          Molecular Function: ion channel transporter

          Function(s)
          calcium ion transport manganese ion transport gamma-aminobutyric acid secretion oligodendrocyte differentiation regulation of cytosolic calcium ion concentration regulation of calcium ion transport calcium ion import calcium ion transmembrane transport transport ion transport transmembrane transport
          Process(es)
          calcium channel activity protein binding beta-catenin binding store-operated calcium channel activity cadherin binding inositol 1,4,5 trisphosphate binding ion channel activity
          It has to be done as per old AB suggested Products section.
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          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

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