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TRPC4 Antibody (PA5-95508) in WB
Western blot analysis of TRPC4 in Lane 1: human HeLa whole cell lysates, Lane 2: human COLO-320 whole cell lysates, Lane 3: human MCF-7 whole cell lysates, Lane 4: human 293T whole cell lysates. Electrophoresis was performed with 5-20% SDS-PAGE gel (70V, Stacking gel; 90V Resolving gel, Time: 2-3 hours), transferred to a nitrocellulose membrane and blocked using 5% Non-fat Milk/TBS (1.5 hrs at room temperature). Samples were incubated with TRPC4 polyclonal antibody (Product # PA5-95508) using a 0.5 µg/mL dilution, followed by a goat anti-r... View More
Product Details
PA5-95508
产品规格
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
A synthetic peptide corresponding to a sequence of human TRPC4 (MAQFYYKRNVNAPYRDRIPLRIVRAESEL).
Conjugate
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2807310
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. TRPC4 forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4. The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7). Diseases associated with TRPC4 include Photosensitive Epilepsy.CaV3.3 encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by CaV3.3 is characterized by a slower activation and inactivation compared to other T-type calcium channels. CaV3.3 may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants of CaV3.3. Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization, an proteins such as CaV3.3 regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Diseases associated with CACNA1I include Childhood Absence Epilepsy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: alpha TRPC4; beta TRPC4; beta-2 TRPC4; capacitative calcium entry channel 1; Capacitative calcium entry channel Trp4; CCE1; hTrp-4; MGC119570; MGC119571; MGC119572; MGC119573; putative capacitative calcium entry channel; Receptor-activated cation channel TRP4; Short transient receptor potential channel 4; transient receptor potential cation channel, subfamily C, member 4; transient receptor potential channel 4; transient receptor potential protein 4; transient receptor protein 4; Trp-related protein 4; TRPC 4; TrpC4; Trpc4_v2
Gene Aliases: CCE1; HTRP-4; HTRP4; STRPC4; TRP4; TRPC4; Trrp4
UniProt ID: (Human) Q9UBN4, (Mouse) Q9QUQ5
Entrez Gene ID: (Human) 7223, (Rat) 84494, (Mouse) 22066
Molecular Function:
ion channel
transporter
calcium ion transport
manganese ion transport
gamma-aminobutyric acid secretion
oligodendrocyte differentiation
regulation of cytosolic calcium ion concentration
regulation of calcium ion transport
calcium ion import
calcium ion transmembrane transport
transport
ion transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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