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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
0.1-0.5 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthetic peptide corresponding to a sequence of human TRPC4. |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
浓度 |
500 µg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS with 4mg trehalose |
内含物 |
0.05mg sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2807310 |
Synthetic peptide sequence: MAQFYYKRNVNAPYRDRIPLRIVRAESEL.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels. TRPC4 forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4. The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7). Diseases associated with TRPC4 include Photosensitive Epilepsy.CaV3.3 encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by CaV3.3 is characterized by a slower activation and inactivation compared to other T-type calcium channels. CaV3.3 may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants of CaV3.3. Voltage-gated calcium channels (CaV) are present in the membrane of most excitable cells and mediate calcium influx in response to depolarization, an proteins such as CaV3.3 regulate intracellular processes such as contraction, secretion, neurotransmission and gene expression. Diseases associated with CACNA1I include Childhood Absence Epilepsy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: alpha TRPC4; beta TRPC4; beta-2 TRPC4; capacitative calcium entry channel 1; Capacitative calcium entry channel Trp4; CCE1; hTrp-4; MGC119570; MGC119571; MGC119572; MGC119573; putative capacitative calcium entry channel; Receptor-activated cation channel TRP4; Short transient receptor potential channel 4; transient receptor potential cation channel, subfamily C, member 4; transient receptor potential channel 4; transient receptor potential protein 4; transient receptor protein 4; Trp-related protein 4; TRPC 4; TrpC4; Trpc4_v2
基因别名: CCE1; HTRP-4; HTRP4; STRPC4; TRP4; TRPC4; Trrp4
UniProt ID: (Human) Q9UBN4, (Mouse) Q9QUQ5
Entrez Gene ID: (Human) 7223, (Rat) 84494, (Mouse) 22066
分子生物学功能:
ion channel
transporter
