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Peptide Sequence: VANEESEHNQ ASIVFPPPGA SEENGLPHTS ARTQLPQSMK IMHEIMYKLE VLYVLCVLLM GRQRNQVHRM IAEFKLIPGL NNLFDKLIWR KHSASALVLH GHNQNCDCSP D
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.
蛋白别名: protein phosphatase 1, regulatory subunit 158; Protein TAP1; Protein TRUSS; short transient receptor potential channel 4 associated protein; Short transient receptor potential channel 4-associated protein; TAP1 protein; TNF-receptor; TNF-receptor ubiquitous scaffolding/signaling protein; TP4AP; transient receptor potential cation channel, subfamily C, member 4 associated protein; TRP4-associated protein; trpc4-associated protein; tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein
基因别名: C20orf188; PPP1R158; TRPC4AP; TRRP4AP; TRUSS
UniProt ID: (Human) Q8TEL6
Entrez Gene ID: (Human) 26133