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Invitrogen
TSKU Polyclonal Antibody
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产品信息
PA5-52523
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: DTAHLDLSSN RLEMVNESVL AGPGYTTLAG LDLSHNLLTS ISPTAFSRLR YLESLDLSHN GLTALPAESF TSSPLSDVNL SHNQLREVSV SAFTTHSQGR ALHVDLSHNL IHR
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
靶标信息
The TSKU gene encodes Tsukushi, a member of the small leucine-rich proteoglycan (SLRP) family, playing crucial roles in cellular signaling, growth, and development. Tsukushi is characterized by its involvement in various biological processes, including immune regulation, tissue remodeling, and metabolic homeostasis. It is a hepatokine released in response to conditions like nonalcoholic fatty liver disease (NAFLD), influencing metabolic traits and contributing to conditions such as dyslipidemia and cardiovascular diseases. Tsukushi impacts energy expenditure by modulating brown fat thermogenesis, thereby affecting metabolic homeostasis and obesity-related metabolic traits. As an extracellular matrix component, Tsukushi participates in signaling pathways that regulate cell proliferation, migration, and differentiation, impacting organ development and pathophysiological processes. Its role in metabolic and inflammatory diseases presents it as a potential biomarker and therapeutic target in conditions characterized by altered metabolic and inflammatory states. Ongoing research further elucidates Tsukushi's mechanisms and interactions, contributing to our understanding of its multifunctional roles in health and disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E2-induced gene 4 protein; Early insulin-induced hepatic gene protein; EIIH; hepatic protein EIIH; leucine rich repeat containing 54; Leucine-rich repeat-containing protein 54; Tsukushi; tsukushi homolog; tsukushi small leucine rich proteoglycan homolog; tsukushin
基因别名: 9530051K01Rik; E2IG4; Eiih; LRRC54; TSK; TSKU; UNQ850/PRO1788
UniProt ID: (Human) Q8WUA8, (Rat) Q6QMY6, (Mouse) Q8CBR6
Entrez Gene ID: (Human) 25987, (Rat) 308843, (Mouse) 244152
