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Proteintech
TTBK2 Polyclonal Antibody
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产品信息
15072-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
TTBK2 Fusion Protein Ag7108 (1-354 aa encoded by BC071556)
偶联物
形式
Liquid
浓度
0.37 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
15072-1-AP has a cross reaction with TTBK1.
Immunogen sequence: MSGGGEQPD ILSVGILVKE RWKVLRKIGG GGFGEIYDAL DMLTRENVAL KVESAQQPKQ VLKMEVAVLK KLQGKDHVCR FIGCGRNDRF NYVVMQLQGR NLADLRRSQS RGTFTISTTL RLGRQILESI ESIHSVGFLH RDIKPSNFAM GRFPSTCRKC YMLDFGLARQ FTNSCGDVRP PRAVAGFRGT VRYASINAHR NREMGRHDDL WSLFYMLVEF VVGQLPWRKI KDKEQVGSIK ERYDHRLMLK HLPPEFSIFL DHISSLDYFT KPDYQLLTSV FDNSIKTFGV IESDPFDWEK TGNDGSLTTT TTSTTPQLHT RLTPAAIGIA NATPIPGDLL RENTDEVFPD EQLSD (1-354 aa encoded by BC071556)
靶标信息
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Protein bartleby; tau tubulin kinase 1; Tau-tubulin kinase 2
基因别名: 2610507N02Rik; AI326283; B930008N24Rik; Bby; KIAA0847; mKIAA0847; SCA11; TTBK; Ttbk1; TTBK2; TTK
UniProt ID: (Human) Q6IQ55, (Mouse) Q3UVR3
Entrez Gene ID: (Human) 146057, (Rat) 311349, (Mouse) 140810
