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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: tau tubulin kinase 1; Tau-tubulin kinase 2
基因别名: KIAA0847; SCA11; TTBK; Ttbk1; TTBK2
UniProt ID: (Human) Q6IQ55
Entrez Gene ID: (Human) 146057, (Rat) 311349
