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This target displays homology in the following species: Human: 100%
This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia, primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Outer dynein arm-docking complex subunit 4; Tetratricopeptide repeat protein 25; TPR repeat protein 25
基因别名: ODAD4; TTC25
UniProt ID: (Human) Q96NG3
Entrez Gene ID: (Human) 83538