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Invitrogen
TTC3 Polyclonal Antibody
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产品信息
PA5-53494
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human TTC3
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: ATGTFFSRYG ASLKLLDFSI MTFLWNEKYG HKLDSIEGKQ LDYFSEPASL KEARCLIWLL EEHRDKFPAL HSALDEFFDI MDSRCTVLRK QDSGEAPFSS TKVKNKSKKK KPKDSKPMLV GSGTTSVTSN NEI
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 84%.
靶标信息
E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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