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The antibody detects endogenous levels of total TTI1 protein.
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Protein SMG10; smg-10 homolog, nonsense mediated mRNA decay factor; Tel two interacting protein 1; Tel2 interacting protein 1 homolog; TEL2-interacting protein 1 homolog; TELO2-interacting protein 1 homolog
基因别名: 2610036D13Rik; AI449463; KIAA0406; smg-10; SMG10; TTI1
UniProt ID: (Human) D6W4K3, (Mouse) Q91V83
Entrez Gene ID: (Human) 9675, (Mouse) 75425