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产品信息
PA5-50852
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:25-1:100 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to residues near the N terminal of human TELO2 interacting protein 1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
2.7 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636304 |
产品详细信息
The antibody detects endogenous levels of total TTI1 protein.
靶标信息
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein SMG10; smg-10 homolog, nonsense mediated mRNA decay factor; Tel two interacting protein 1; Tel2 interacting protein 1 homolog; TEL2-interacting protein 1 homolog; TELO2-interacting protein 1 homolog
基因别名: 2610036D13Rik; AI449463; KIAA0406; smg-10; SMG10; TTI1
UniProt ID: (Human) D6W4K3, (Mouse) Q91V83
Entrez Gene ID: (Human) 9675, (Mouse) 75425
