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Invitrogen
TUBA1B/TUBA4A Recombinant Rabbit Monoclonal Antibody (24GB2020)
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TUBA1B/TUBA4A Antibody (MA5-57299) in ICC/IF
Immunocytochemical staining of TUBA1B/TUBA4A in HepG2 cells using TUBA1B/TUBA4A Recombinant Monoclonal Antibody (Product # MA5-57299) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; alpha 1B/4A Tubulin was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
产品信息
MA5-57299
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
24GB2020
抗原
A synthesized peptide derived from human TUBA1B/4A (aa 33-47)
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
TUBA1B and TUBA4A are genes that encode for alpha-tubulin isoforms, essential components of the microtubule system that plays a critical role in maintaining cell structure, intracellular transport, and cell division. TUBA1B, also known as tubulin alpha-1b chain, is located on chromosome 12q13.12 and has been linked to various cancers due to its influence on microtubule dynamics and cellular proliferation. It is also associated with immune cell infiltration and modulation of immune checkpoints, making it significant in tumor growth and metastasis. TUBA4A, known as tubulin alpha-4A, is found on chromosome 2q35 and is linked to neurodevelopmental disorders and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in TUBA4A can lead to defects in microtubule stability and function, emphasizing its role in neuronal health. Both genes highlight the critical role of microtubules in cellular and neurological functions, and their mutations can contribute to diverse pathological conditions, including cancer and neurodegenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha tubulin; Alpha-tubulin 1; Alpha-tubulin 2; Alpha-tubulin 4; Alpha-tubulin isotype M-alpha-2; Alpha-tubulin isotype M-alpha-4; Alpha-tubulin ubiquitous; Testis-specific alpha-tubulin; Tubulin alpha-1 chain; Tubulin alpha-1B chain; Tubulin alpha-2 chain; Tubulin alpha-4 chain; Tubulin alpha-4A chain; Tubulin alpha-ubiquitous chain; Tubulin H2-alpha; Tubulin K-alpha-1; tubulin, alpha 1 (testis specific); tubulin, alpha 1b; tubulin, alpha 2; tubulin, alpha 4; tubulin, alpha 4a; tubulin, alpha, ubiquitous
基因别名: ALS22; H2-ALPHA; K-ALPHA-1; M[a]4; RGD1565476; TUBA1; TUBA1B; Tuba2; Tuba4; TUBA4A
UniProt ID: (Human) P68363, (Human) P68366, (Mouse) P05213, (Rat) Q6P9V9, (Rat) Q5XIF6, (Mouse) P68368
Entrez Gene ID: (Human) 10376, (Human) 7277, (Mouse) 22143, (Rat) 500929, (Rat) 316531, (Mouse) 22145
microtubule cytoskeleton organization
microtubule-based process
cytoskeleton-dependent intracellular transport
cell division
cellular response to interleukin-4
G2/M transition of mitotic cell cycle
platelet degranulation
cytoskeleton organization
protein polymerization
metabolic process
biological_process
