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Immunogen sequence: MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS DLSKMAAIYL VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNIP KYDLLYQDI; Positive Samples: Mouse liver; Cellular Location: Nucleus
Dim2, also known as TXNL4B (thioredoxin-like 4B), or DLP, is a 149 amino acid nuclear protein that exists as a homodimer and plays an essential role in pre-mRNA splicing. Evolutionarily related and sharing 38% sequence identity with Dim1, Dim2 is required for S/G(2) transition during the cell cycle and is able to bind the PRP6 (U5-102K) subunit of the spliceosome. The gene encoding Dim2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Dim1-like protein; thioredoxin-like 4B; Thioredoxin-like protein 4B
基因别名: AI595343; D530025J19Rik; DIM2; DLP; TXNL4B
UniProt ID: (Human) Q9NX01, (Mouse) Q8BUH1
Entrez Gene ID: (Human) 54957, (Mouse) 234723
分子生物学功能:
oxidoreductase
