Invitrogen

TXNL4B Polyclonal Antibody

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TXNL4B Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry-Immunofluorescence analysis of TXNL4B was performed in A-549 cells using TXNL4B Polyclonal Antibody (Product # PA5-96584).

TXNL4B Antibody in Western Blot (WB) — Western Blot analysis of TXNL4B in extracts of mouse liver using TXNL4B Polyclonal Antibody (Product # PA5-96584) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST.

产品信息

PA5-96584

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:2,000	-
免疫细胞化学 (ICC/IF)	1:50 - 1:100	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Recombinant fusion protein containing a sequence corresponding to amino acids 1-149 of human TXNL4B.
偶联物	Unconjugated
形式	Liquid
浓度	1.65 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.3, with 50% glycerol
内含物	0.02% sodium azide
保存条件	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2808386

产品详细信息

Immunogen sequence: MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS DLSKMAAIYL VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNIP KYDLLYQDI; Positive Samples: Mouse liver; Cellular Location: Nucleus

靶标信息

Dim2, also known as TXNL4B (thioredoxin-like 4B), or DLP, is a 149 amino acid nuclear protein that exists as a homodimer and plays an essential role in pre-mRNA splicing. Evolutionarily related and sharing 38% sequence identity with Dim1, Dim2 is required for S/G(2) transition during the cell cycle and is able to bind the PRP6 (U5-102K) subunit of the spliceosome. The gene encoding Dim2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

仅用于科研。不用于诊断过程。未经明确授权不得转售。