Invitrogen

TYRO3 Recombinant Rabbit Monoclonal Antibody (14H68L29)

高级验证

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

查看其他16个TYRO3抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (1)
高级验证 (1)

TYRO3 Antibody in Immunocytochemistry (ICC/IF)

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TYRO3 Antibody (703295) in ICC/IF

For immunofluorescence analysis, PC-12 cells were fixed and permeabilized for detection of endogenous TYRO3 using Anti-TYRO3 Recombinant Rabbit Monoclonal Antibody (Product # 703295, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Nuclei (blue) were stained using ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). Panel a-c) shows representative undifferentiated cells that were stained for detection and localization of T... View More

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TYRO3 Antibody — Detection of subcellular localization of the target protein by cell treatment demonstrates antibody specificity. Immunofluorescence analysis of TYRO3 using Anti-TYRO3 Recombinant Rabbit Monoclonal Antibody (Product # 703295) detects TYRO3 on the membrane of PC-12 cells treated and differentiated with NGF in comparison to control cells. {TM}

产品信息

703295

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

1:100

产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Monoclonal

类型

Antibody

克隆号

14H68L29

抗原

Protein corresponding to human TYRO3 [aa790-aa890]

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偶联物

Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2784573

产品详细信息

This antibody is predicted to react with Human, Monkey, Pig, Bovine, Cat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Bruton agammaglobulinemia tyrosine kinase; FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; tyro 3; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF

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基因别名: Brt; BYK; DTK; Etk-2; Rek; RSE; SKY; TIF; TYRO3

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UniProt ID: (Human) Q06418, (Rat) P55146

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Entrez Gene ID: (Human) 7301, (Rat) 25232

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功能

virus receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity protein binding ATP binding phosphatidylinositol 3-kinase binding protein heterodimerization activity transmembrane signal receptor

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