FIGURE: 1 / 1
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245). [UniProt]
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Poly [ADP-ribose] polymerase 5B; Poly [ADP-ribose] polymerase tankyrase-2; Protein poly-ADP-ribosyltransferase tankyrase-2; TANK2; Tankyrase II; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase-2; Tankyrase-like protein; Tankyrase-related protein; tnks 2; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Gene Aliases: ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C; pART6; TANK2; TNKL; TNKS2
UniProt ID: (Human) Q9H2K2
Entrez Gene ID: (Human) 80351
Molecular Function: kinase inhibitor