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Product Details
PA5-17930
产品规格
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Synthetic peptide sequence (RECOMBINANT2) corresponding to the internal amino acids of TNKS2
Conjugate
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_10979900
Product Specific Information
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
Target Information
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Poly [ADP-ribose] polymerase 5B; Poly [ADP-ribose] polymerase tankyrase-2; Protein poly-ADP-ribosyltransferase tankyrase-2; TANK2; Tankyrase II; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase-2; Tankyrase-like protein; Tankyrase-related protein; tnks 2; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Gene Aliases: ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C; pART6; TANK2; TNKL; TNKS2
UniProt ID: (Human) Q9H2K2
Entrez Gene ID: (Human) 80351
Molecular Function:
kinase inhibitor
protein polyubiquitination
protein ADP-ribosylation
Wnt signaling pathway
positive regulation of telomere maintenance via telomerase
multicellular organism growth
regulation of multicellular organism growth
protein localization to chromosome, telomeric region
protein auto-ADP-ribosylation
positive regulation of canonical Wnt signaling pathway
positive regulation of telomere capping
negative regulation of telomere maintenance via telomere lengthening
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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