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Invitrogen
Tapasin Polyclonal Antibody
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Tapasin Antibody (PA5-96016) in IHC (P)
Immunohistochemistry analysis of Tapasin in paraffin-embedded human gastric cancer. Samples were incubated with Tapasin Polyclonal antibody (Product # PA5-96016) using a dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-96016
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 30-260 of human TAPBP (NP_7573452)
偶联物
形式
Liquid
浓度
2.22 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: VEDASGKGLA KRPGALLLRQ GPGEPPPRPD LDPELYLSVH DPAGALQAAF RRYPRGAPAP HCEMSRFVPL PASAKWASGL TPAQNCPRAL DGAWLMVSIS SPVLSLSSLL RPQPEPQQEP VLITMATVVL TVLTHTPAPR VRLGQDALLD LSFAYMPPTS EAASSLAPGP PPFGLEWRRQ HLGKGHLLLA ATPGLNGQMP AAQEGAVAFA AWDDDEPWGP WTGNGTFWLP T; Positive Samples: HT-29; Cellular Location: Endoplasmic reticulum membrane, Single-pass type I membrane protein
靶标信息
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DADB-159G18.7; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin; TPN; TPSN
基因别名: D17Wsu91e; NGS17; TAPA; TAPBP; TPN; TPSN
UniProt ID: (Human) O15533, (Mouse) Q9R233
Entrez Gene ID: (Human) 6892, (Rat) 25217, (Mouse) 21356
antigen processing and presentation of peptide antigen via MHC class I
protein complex assembly
retrograde vesicle-mediated transport, Golgi to ER
immune response
regulation of gene expression
antigen processing and presentation of endogenous peptide antigen via MHC class I
peptide antigen stabilization
transmembrane transport
regulation of protein complex stability
MHC class I protein complex assembly
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
defense response
