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MA5-11466 targets Terminal Deoxyribonucleotidyl Transferase in IHC (P) applications and shows reactivity with Human samples.
The MA5-11466 immunogen is recombinant protein corresponding to the amino terminal region of the TdT molecule.
Terminal Deoxynucleotidyl Transferase (TdT) is a DNA polymerase located in the cell nucleus which catalyses the polymerization of deoxynucleotides at the 3' hydroxyl ends of oligo or polydeoxynucleotide initiators and functions without a template. TdT is considered to be a highly specific marker for the diagnosis and classification of acute lymphoblastic lymphoma/leuksemias. The determination of TdT expression is most valuable when it is different to differentiate histologically between lymphoblastic lymphoma and Burkitt's lymphoma.
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