Immunogen sequence: TSFTTGGLRI PFPRDCGEEM QNGAGASRTS TIFLNGNRER PLNVFCDMET DGGGWLVFQR RMDGQTDFWR DWEDYAHGFG NISGEFWLGN EALHSLTQAG DYSMRVDLRA GDEAVFAQYD SFHVDSAAEY YRLHLEGYHG TAGDSMSYHS GSVFSARDRD PNSLLISCAV SYRGAWWYRN CHYANLNGLY GSTVDHQGVS WYHWKGFEFS VPFTEMKLRP RNFRSPAGGG; Positive Samples: Mouse liver, Mouse kidney, Rat liver; Cellular Location: extracellular matrix, extracellular space
Tenascin-X (TNXB) is a extracellular matrix glycoprotein predominantly located in the outer reticular lamina of the basement membrane (BM). It interacts with many other ECM proteins and it accelerates collagen fibrillogenesisin vitro. TNXB plays a role in interactions between cell and ECM, antiadhesive effect, inhibiting cell migration, and in maintaining homeostasis of the extracellular matrix. Deficiency of TNXB has been associated with the connective tissue disorder Ehlers-Danlos syndrome.
蛋白别名: growth-inhibiting protein 45; Hexabrachion-like protein; tenascin XB1; tenascin XB2; Tenascin-X; TN-X; TNXB2tenascin XB1; TNXBSTNXTENX; XB-S; XBTN-X
基因别名: EDS3; HXBL; TENX; Tn-mhc; TN-X; TNX; TNXB; TNXB1; TNXB2; TNXBS; VUR8; XB; XBS
UniProt ID: (Human) P22105
分子生物学功能: extracellular matrix protein