Invitrogen

Thrombospondin 1 Polyclonal Antibody

View all (18) Thrombospondin 1 antibodies
Datasheet
Protocols
Tech Support
Datasheet
Protocols
Tech Support

Product Details

PA5-95445

Applications
Tested Dilution
Publications

免疫印迹 (WB)

0.1-0.5 µg/mL
-

酶联免疫吸附实验 (ELISA)

0.1-0.5 µg/mL
-
产品规格

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

分类

Polyclonal

类型

Antibody

Immunogen

E.coli-derived human Thrombospondin recombinant protein (Position: D27-H112).
View immunogen

Conjugate

Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Affinity chromatography

保存液

PBS with 4mg trehalose

内含物

0.05mg sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2807248

Product Specific Information

Human Thrombospondin shares 81.4% amino acid (aa) sequence identity with mouse Thrombospondin.

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Glycoprotein G; Thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1

View more View less

Gene Aliases: tbsp1; THBS; THBS-1; THBS1; TSP; TSP-1; TSP1

View more View less

UniProt ID: (Human) P07996

View more View less

Entrez Gene ID: (Human) 7057, (Rat) 445442, (Mouse) 21825

View more View less

Function(s)
activation of MAPK activity response to hypoxia negative regulation of endothelial cell proliferation negative regulation of cell-matrix adhesion sprouting angiogenesis chronic inflammatory response platelet degranulation negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II negative regulation of dendritic cell antigen processing and presentation inflammatory response immune response response to unfolded protein cell cycle arrest cell adhesion response to glucose positive regulation of endothelial cell migration negative regulation of endothelial cell migration negative regulation of plasma membrane long-chain fatty acid transport negative regulation of nitric oxide mediated signal transduction negative regulation of cGMP-mediated signaling negative regulation of plasminogen activation positive regulation of macrophage chemotaxis positive regulation of fibroblast migration cell migration negative regulation of angiogenesis peptide cross-linking positive regulation of blood coagulation extracellular matrix organization positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway regulation of cGMP metabolic process response to magnesium ion response to progesterone negative regulation of interleukin-12 production positive regulation of transforming growth factor beta1 production cellular response to heat response to endoplasmic reticulum stress protein O-linked fucosylation negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of phosphorylation response to drug positive regulation of tumor necrosis factor biosynthetic process positive regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration engulfment of apoptotic cell positive regulation of translation positive regulation of angiogenesis behavioral response to pain positive regulation of chemotaxis response to calcium ion negative regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of fibrinolysis positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process negative regulation of endothelial cell chemotaxis negative regulation of extrinsic apoptotic signaling pathway outflow tract morphogenesis endocardial cushion development growth plate cartilage development response to mechanical stimulus positive regulation of cell-substrate adhesion response to testosterone blood vessel morphogenesis cellular response to tumor necrosis factor cellular response to growth factor stimulus positive regulation of transforming growth factor beta production cellular response to nitric oxide
Process(es)
phosphatidylserine binding glycoprotein binding fibronectin binding integrin binding calcium ion binding protein binding heparin binding fibroblast growth factor binding low-density lipoprotein particle binding identical protein binding laminin binding proteoglycan binding transforming growth factor beta binding fibrinogen binding collagen V binding extracellular matrix binding
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support