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Invitrogen
Tick-Borne Encephalitis Virus NS2B Recombinant Rabbit Monoclonal Antibody (HL4147)
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Tick-Borne Encephalitis Virus NS2B Antibody (MA568422) in WB
Western blot analysis of Tick-Borne Encephalitis Virus NS2B in Non-transfected (–) and transfected (+) 293T whole cell extracts. Samples were incubated with Tick-Borne Encephalitis Virus NS2B recombinant monoclonal antibody (Product # MA568422) using a dilution of 1:12,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
MA568422
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL4147
抗原
Recombinant fragment of Tick-borne encephalitis virus NS2B.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Tick-Borne Encephalitis Virus (TBEV) non-structural protein 2B (NS2B) is a cofactor that plays a crucial role in the viral NS2B/NS3 protease complex, which is essential for viral replication and polyprotein processing. The NS2B protein acts as an indispensable partner to the NS3 protease, enhancing its proteolytic activity necessary for cleaving the viral polyprotein into functional units. This complex is critical for generating mature viral proteins such as C (capsid), prM (precursor membrane protein), and others necessary for the viral life cycle. Mutations and variations in the NS2B region can significantly impact protease function, affecting viral replication efficiency and pathogenicity. Structural studies of the NS2B-NS3 protease have provided insights into its mechanism, guiding the development of inhibitors aimed at disrupting this protease activity to curb viral proliferation. Targeting the NS2B-NS3 interaction represents a promising therapeutic strategy for treating TBEV infections, given the essential role of this protease complex in the viral replication process.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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