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Invitrogen
Tn Antigen Monoclonal Antibody (Tn 218)
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产品信息
MA1-90544
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
Tn 218
抗原
Asialo ovine submaxillary mucin (AOSM).
偶联物
形式
Liquid
浓度
0.20 mg/mL
保存液
PBS, pH 7.2
内含物
0.05% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-90544 stains Tn antigen in epithelial carcinoma, pancreatic, colon, stomach and breast.
A suggested positive control for this product is human gastrointestinal tumor.
The antibody is supplied as concentrated tissue culture supernatant in PBS with 0.05% azide.
靶标信息
Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approximately 90% of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells. Fundamental, chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primamry breast carcinoma demonstrate its highly significant correlation with clinical pathological tumor stages, and hence its value as a reliable prognisticator.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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