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Invitrogen
Tobemstomig Recombinant Human Monoclonal Antibody
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产品信息
MA5-60157
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Tobemstomig is a biosimilar that acts as a bispecific monoclonal antibody targeting the PD-1 (programmed cell death protein 1) and LAG-3 (lymphocyte-activation gene 3) checkpoints. Lymphocyte Activation Gene-3 (LAG3) is a type I transmembrane protein with structural similarities to CD4 and is encoded by the LAG3 gene located on chromosome 12p13. The protein is highly upregulated on exhausted T cells in the tumor microenvironment and functions as an immune checkpoint receptor. Upon binding to MHC class II molecules, LAG3 transmits inhibitory signals to T cells, leading to T cell dysfunction, making it a significant target for cancer immunotherapy. PDCD1, on the other hand, encodes the Programmed Cell Death Protein 1 (PD-1), which is found on chromosome 2q37.3. PD-1 is a receptor expressed on the surface of immune cells, particularly T cells, and interacts with its ligands PD-L1 and PD-L2 to suppress T cell inflammatory activity, thus preventing autoimmunity. Both LAG3 and PD-1 play crucial roles in modulating immune responses, particularly through their inhibitory actions in the tumor microenvironment. These genes are primarily targeted in combination cancer immunotherapies aimed at restoring the immune system's ability to eradicate cancer cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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