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Invitrogen
Tolbutamide Recombinant Mouse Monoclonal Antibody (1D4)
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Tolbutamide Antibody (MA566273) in SDS-PAGE
SDS-PAGE characterization of Tolbutamide under reducing conditions. Lane M: Protein marker (kDa); Lane TLM: Purified Tolbutamide Recombinant Monoclonal (Product # MA566273). Tolbutamide showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-663.
产品信息
MA566273
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1D4
抗原
Conjugate of TLM hapten and KLH.
偶联物
形式
Liquid
浓度
3.5 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Tolbutamide is a first-generation sulfonylurea oral hypoglycemic agent used primarily in the treatment of type-2 diabetes. It functions by stimulating insulin secretion through binding to the high-affinity subunit SUR1 of the beta-cell ATP-sensitive potassium channel (KATP channel). The gene encoding the SUR1 subunit is located on chromosome 11p15.1 and is part of the ABCC8 gene, which plays a critical role in insulin regulation. Structurally, tolbutamide is characterized by its sulfonylurea moiety, which is essential for its hypoglycemic activity. Recent studies have explored the synthesis of tolbutamide derivatives with NO-donor properties, aiming to enhance its biological profile by linking it with furoxan derivatives or classical nitrooxy functions, potentially offering improved therapeutic benefits.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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