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Product Details
PA5-83014
Applications
Tested Dilution
Publications
产品规格
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Recombinant protein corresponding to Human CRTC2
Conjugate
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2790170
Product Specific Information
Immunogen sequence: ALNRTSSDSA LHTSVMNPSP QDTYPGPTPP SILPSRRGGI LDGEMDPKVP AIEENLLDDK HLLKPWDAKK LSSSSSRPRS CEVPGIN
Target Information
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: CREB-regulated transcription coactivator 2; OTTHUMP00000035255; TORC-2; transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated cAMP response element-binding protein 2
Gene Aliases: CRTC2; TORC-2; TORC2
UniProt ID: (Human) Q53ET0
Entrez Gene ID: (Human) 200186
Molecular Function:
transcription cofactor
Performance Guarantee
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