FIGURE: 1 / 1
Immunogen sequence: ALNRTSSDSA LHTSVMNPSP QDTYPGPTPP SILPSRRGGI LDGEMDPKVP AIEENLLDDK HLLKPWDAKK LSSSSSRPRS CEVPGIN
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.
Protein Aliases: CREB-regulated transcription coactivator 2; OTTHUMP00000035255; TORC-2; transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated cAMP response element-binding protein 2
Gene Aliases: CRTC2; TORC-2; TORC2
UniProt ID: (Human) Q53ET0
Entrez Gene ID: (Human) 200186
Molecular Function: transcription cofactor