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NeoBiotechnologies
Transcription factor E3/TFE3 (Transcription Factor) Recombinant Rabbit Monoclonal Antibody (MSVA-403R)
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Transcription factor E3/TFE3 (Transcription Factor) Antibody (7030-RBM4-P1) in IHC (P)
Transcription factor E3 Rabbit Recombinant Monoclonal Antibody (MSVA-403R) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.
产品信息
7030-RBM4-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MSVA-403R
抗原
Recombinant full-length human TFE3 protein.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product cellular localization: Cell membrane, Cytoplasm, Secreted.
Positive control: Human lung, placenta or spleen.
Tissue specificity: Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.
靶标信息
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHe33; Class E basic helix-loop-helix protein 33; transcription factor E family, member A; Transcription factor E3; transcription factor for IgH enhancer; transcription factor for immunoglobulin heavy-chain enhancer 3
基因别名: BHLHE33; RCCP2; RCCX1; TFE3; TFEA
UniProt ID: (Human) P19532
Entrez Gene ID: (Human) 7030
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription regulatory region DNA binding
protein dimerization activity
