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This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01EU/ug.
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti Human CD71 antibody, clone DF1513 recognizes the human CD71 cell surface antigen, a approximately 190 kDa homodimeric glycoprotein expressed by proliferating cells.
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD antigen CD71; CD71; p90; sTfR; T9; TR; Transferrin receptor protein 1; Transferrin receptor protein 1, serum form
基因别名: CD71; IMD46; p90; T9; TFR; TFR1; TFRC; TR; TRFR
UniProt ID: (Human) P02786
Entrez Gene ID: (Human) 7037
分子生物学功能:
metalloprotease
