Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Triadin Monoclonal Antibody (GE 4.90)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
MA3-927
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rabbit,
Rat
已发表种属
C. elegans,
Mouse,
Pig,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
GE 4.90
抗原
Purified rabbit fast skeletal muscle triadin.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
ascites
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA3-927 detects triadin from mouse, rabbit and rat tissues.
MA3-927 has been successfully used in Western blot, immunohistochemistry, immunoprecipitation and ELISA procedures. By Western blot, this antibody detects a 95 kDa protein representing triadin from rabbit skeletal muscle extracts. Immunohistochemical staining of triadin in rat skeletal muscle with MA3-927 results in striated staining consistent with sarcoplasmic reticulum localization.
The MA3-927 antigen is purified rabbit fast skeletal muscle triadin.
靶标信息
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR's) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR's), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR's and RyR's. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cardiac triadin; junctional sarcoplasmic reticulum glycoprotein; Triadin; triadin 1; triadin 32 kDa (TRISK 32); triadin 49 kDa (TRISK 49); triadin 95
基因别名: 2310045H21Rik; EG432451; TDN; TRDN
UniProt ID: (Rabbit) Q28820, (Rat) Q9QX75, (Mouse) E9Q9K5
Entrez Gene ID: (Rabbit) 100009519, (Rat) 59299, (Mouse) 76757
cellular calcium ion homeostasis
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to organic cyclic compound
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
myotube differentiation
cytoplasmic microtubule organization
negative regulation of release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
heart contraction
endoplasmic reticulum membrane organization
