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Keep as concentrated solution.
Predicted reactivity: Mouse (97%), Rat (97%), Pig (98%), Chicken (82%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (98%).
Positive Control: mouse brain, rat brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C
基因别名: AW125844; gp145(trkC); GP145-TrkC; NTRK3; Ntrk3_tv3; TRKC
UniProt ID: (Human) Q16288, (Mouse) Q6VNS1, (Rat) Q03351
Entrez Gene ID: (Human) 4916, (Mouse) 18213, (Rat) 29613
分子生物学功能: transmembrane signal receptor