Invitrogen

TrkC Polyclonal Antibody

View all (15) TrkC antibodies
Datasheet
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Datasheet
Protocols
Tech Support

Product Details

PA5-96445

Applications
Tested Dilution
Publications

免疫印迹 (WB)

1:500-1:2,000
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-
产品规格

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

分类

Polyclonal

类型

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human NTRK3.
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Conjugate

Unconjugated

形式

Liquid

浓度

0.58 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2808247

Product Specific Information

Immunogen sequence: KTEINCRRPD DGNLFPLLEG QDSGNSNGNA SINITDISRN ITSIHIENWR SLHTLNAVDM ELYTGLQKLT IKNSGLRSIQ PRAFAKNPHL RYINLSSNRL TTLSWQLFQT LSLRELQLEQ NFFNCSCDIR WMQLWQEQGE AKLNSQNLYC INADGSQLPL FRMNISQCDL PEISVSHVNL TVREGDNAVI TCNGSGSPLP DVDWIVTGLQ SINTHQTNLN WTNVHAINLT LVNVTSEDNG FTLTCIAENV VGMSNASVAL T; Positive Samples: A-549, BT-474, HepG2, Mouse brain, MCF7, Mouse liver; Cellular Location: Membrane, Single-pass type I membrane protein

Target Information

NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Bioinformatics

Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C

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Gene Aliases: AW125844; gp145(trkC); GP145-TrkC; NTRK3; Ntrk3_tv3; TRKC

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UniProt ID: (Human) Q16288, (Mouse) Q6VNS1, (Rat) Q03351

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Entrez Gene ID: (Human) 4916, (Mouse) 18213, (Rat) 29613

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Molecular Function: transmembrane signal receptor

Function(s)
activation of MAPK activity neuron migration negative regulation of protein phosphorylation positive regulation of protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway heart development circadian rhythm positive regulation of cell proliferation positive regulation of gene expression peptidyl-tyrosine phosphorylation modulation by virus of host transcription positive regulation of cell migration activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation neurotrophin signaling pathway mechanoreceptor differentiation positive regulation of apoptotic process response to ethanol protein autophosphorylation ephrin receptor signaling pathway neuron fate specification response to axon injury positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation positive regulation of positive chemotaxis response to corticosterone positive regulation of synapse assembly negative regulation of cell death lens fiber cell differentiation cellular response to retinoic acid cochlea development activation of GTPase activity positive regulation of actin cytoskeleton reorganization protein phosphorylation multicellular organism development nervous system development phosphorylation cell differentiation
Process(es)
p53 binding GPI-linked ephrin receptor activity neurotrophin receptor activity protein binding ATP binding neurotrophin binding nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding
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