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Invitrogen
Trypsin 2 Polyclonal Antibody
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Trypsin 2 Antibody (PA5-121156) in WB
Western blot analysis of Trypsin 2 in extracts of various cell lines. Samples were incubated with Trypsin 2 Polyclonal antibody (Product # PA5-121156) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-121156
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1).
偶联物
形式
Liquid
浓度
2.37 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: Mouse spleen, Mouse skeletal muscle. The target is usually found in the following locations: Secreted, extracellular space.
Immunogen sequence: IVGGYICEEN SVPYQVSLNS GYHFCGGSLI SEQWVVSAGH CYKSRIQVRL GEHNIEVLEG NEQFINAAKI IRHPKYNSRT LDNDILLIKL SSPAVINSRV SAISLPTAPP AAGTESLISG WGNTLSSGAD YPDELQCLDA PVLSQAECEA SYPGKITNNM FCVGFLEGGK DSCQGDSGGP VVSNGELQGI VSWGYGCAQK NRPGVYTKVY NYVDWIKDTI AANS
靶标信息
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Anionic trypsin II; Anionic trypsin-2; Anionic trypsinogen; EC 3.4.21; EC 3.4.21.4; MGC111183; MGC120174; MGC120175; Pretrypsinogen II; protease serine 2 preproprotein; protease, serine, 2; protease, serine, 2 (trypsin 2); Serine protease 2; trypsin 2; Trypsin II; trypsin Trypsin II; Trypsin-2; trypsinogen 2; trypsinogen 20
基因别名: PRSS2; Ta; Tesp4; TRY2; TRY8; TRYP; TRYP2
UniProt ID: (Human) P07478, (Mouse) P07146
Entrez Gene ID: (Human) 5645, (Mouse) 22072
