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Immunogen sequence: ANIMGHLNQH GFYSVLQILL TRGLARPRPC LSKGTLTAAF SLALRPVIAA QFSDNLIRPF LIHIMSVPAL VTHLSTVTPE RLTVLESHDM LRKFIIFLRD QDRCRDV
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 85%.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: HECT-type ubiquitin transferase E3B; UBE3B_v2; Ubiquitin-protein ligase E3B
基因别名: BPIDS; KOS; UBE3B
UniProt ID: (Human) Q7Z3V4
Entrez Gene ID: (Human) 89910
分子生物学功能: ubiquitin-protein ligase