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Bethyl Laboratories
UBQLN4/CIP75/Ubiquilin 4 Polyclonal Antibody
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UBQLN4/CIP75/Ubiquilin 4 Antibody (A305-237A-M) in WB
Detection of human UBQLN4 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, 293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-UBQLN4 antibody A305-237A-M (lot A305-237A-M-1) used for WB at 1:1000. Detection: Chemiluminescence with an exposure time of 3 minutes.
产品信息
A305-237A-M
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 1 to 50 of Human Ubiquilin-4.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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