Proteintech

UBXN1 Polyclonal Antibody

Name: UBXN1 Polyclonal Antibody
Brand: Proteintech
SKU: 16135-1-AP

12 篇参考文献

查看其他6个UBXN1抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (10)

UBXN1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 10

UBXN1 Antibody (16135-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using (Product # 16135-1-AP) (UBXN1 antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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产品信息

16135-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2400

查看8篇已发表文章 8篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:1,000

免疫细胞化学 (ICC/IF)

Assay-dependent

查看2篇已发表文章 2篇已发表文章

免疫沉淀 (IP)

Assay-dependent

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

UBXN1 Fusion Protein Ag9146 (1-297 aa encoded by BC000902)

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.31 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MAELTALES LIEMGFPRGR AEKALALTGN QGIEAAMDWL MEHEDDPDVD EPLETPLGHI LGREPTSSEQ GGLEGSGSAA GEGKPALSEE ERQEQTKRML ELVAQKQRER EEREEREALE RERQRRRQGQ ELSAARQRLQ EDEMRRAAEE RRREKAEELA ARQRVREKIE RDKAERAKKY GGSVGSQPPP VAPEPGPVPS SPSQEPPTKR EYDQCRIQVR LPDGTSLTQT FRAREQLAAV RLYVELHRGE ELGGGQDPVQ LLSGFPRRAF SEADMERPLQ ELGLVPSAVL IVAKKCPS (1-297 aa encoded by BC000902)

靶标信息

Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling (PubMed:23545497). Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibiting their recruitment to TNFR1 (PubMed:25681446). Prevents also the activation of NF-kappa-B by associating with CUL1 and thus inhibiting NF-kappa-B inhibitor alpha/NFKBIA degradation that remains bound to NF-kappa-B (PubMed:28152074). Interacts with the BRCA1-BARD1 heterodimer and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1 leads to the inhibition of the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (PubMed:20351172). Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。