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Proteintech
UCP2 Monoclonal Antibody (2B4B1)
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产品信息
66700-1-IG
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG3
分类
Monoclonal
类型
Antibody
克隆号
2B4B1
抗原
UCP2 Fusion Protein Ag19361 (1-309 aa encoded by BC011737)
偶联物
形式
Liquid
浓度
0.83 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody detect a band around 28-33 kDa corresponding to UCP2 protein in mouse liver, skeletal muscle and pancreas. Some upper and lower bands also were observed due to the dimer formation and degradation of the UCP2 protein. This antibody was raised against the full-length UCP2 protein and may cross-react with UCP3. It is notable that UCP2 is known to have a very short half-life less than 1 hour. It is strongly recommended that fresh-made lysate be used for western blot assays.
Immunogen sequence: MVGFKATDV PPTATVKFLG AGTAACIADL ITFPLDTAKV RLQIQGESQG PVRATASAQY RGVMGTILTM VRTEGPRSLY NGLVAGLQRQ MSFASVRIGL YDSVKQFYTK GSEHASIGSR LLAGSTTGAL AVAVAQPTDV VKVRFQAQAR AGGGRRYQST VNAYKTIARE EGFRGLWKGT SPNVARNAIV NCAELVTYDL IKDALLKANL MTDDLPCHFT SAFGAGFCTT VIASPVDVVK TRYMNSALGQ YSSAGHCALT MLQKEGPRAF YKGFMPSFLR LGSWNVVMFV TYEQLKRALM AACTSREAPF (1-309 aa encoded by BC011737)
靶标信息
UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dicarboxylate carrier SLC25A8; Mitochondrial uncoupling protein 2; Solute carrier family 25 member 8; UCP 2; UCPH; uncoupling protein; uncoupling protein 2 (mitochondrial, proton carrier)
基因别名: BMIQ4; SLC25A8; UCP2; UCPH
UniProt ID: (Human) P55851
Entrez Gene ID: (Human) 7351
response to superoxide
response to hypoxia
translation
transport
mitochondrial transport
female pregnancy
aging
positive regulation of cell death
proton transport
cellular response to insulin stimulus
cellular response to amino acid starvation
negative regulation of apoptotic process
regulation of mitochondrial membrane potential
negative regulation of insulin secretion involved in cellular response to glucose stimulus
response to fatty acid
cellular response to glucose stimulus
liver regeneration
