Recommended positive controls: 293T, A431, HeLa, HepG2, H1299, mouse liver.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
UGT1A6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
蛋白别名: MGC29860; Phenol UDP-glucuronosyltransferase; Phenol-metabolizing UDP-glucuronosyltransferase; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT 1-6; UGP1A1; UGT-1F; UGT1*6; UGT1-06; UGT1.6; UGT1A6; UGT1A7
基因别名: GNT1; HLUGP; HLUGP1; UDPGT; UDPGT 1-6; UGT1; UGT1-06; UGT1.6; UGT1A6; Ugt1a6a; UGT1A6S; Ugt1a7; UGT1F