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Proteintech
UGT8 Polyclonal Antibody
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产品信息
17982-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
UGT8 Fusion Protein Ag12393 (38-402 aa encoded by BC075069)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody specifically recognizes the endogenous UGT8.
Immunogen sequence: FKTLASALH ERGHHTVFLL SEGRDIAPSN HYSLQRYPGI FNSTTSDAFL QSKMRNIFSG RLTAIELFDI LDHYTKNCDL MVGNHALIQG LKKEKFDLLL VDPNDMCGFV IAHLLGVKYA VFSTGLWYPA EVGAPAPLAY VPEFNSLLTD RMNLLQRMKN TGVYLISRLG VSFLVLPKYE RIMQKYNLLP EKSMYDLVHG SSLWMLCTDV ALEFPRPTLP NVVYVGGILT KPASPLPEDL QRWVNGANEH GFVLVSFGAG VKYLSEDIAN KLAGALGRLP QKVIWRFSGP KPKNLGNNTK LIEWLPQNDL LGHSKIKAFL SHGGLNSIFE TMYHGVPVVG IPLFGDHYDT MTRVQAKGMG ILLEWK (38-402 aa encoded by BC075069)
靶标信息
UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; CGalT; UDP galactosyltransferase 8; UDP galactosyltransferase 8A; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8; UDP-galactose-ceramide galactosyltransferase 8A; UDP-glucuronosyltransferase 8; uridine diphosphate glycosyltransferase 8
基因别名: AI850488; AW455908; CGT; mCerGT; UGT4; UGT8; Ugt8a
UniProt ID: (Human) Q16880, (Rat) Q09426, (Mouse) Q64676
Entrez Gene ID: (Human) 7368, (Rat) 50555, (Mouse) 22239
2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
glucuronosyltransferase activity
N-acylsphingosine galactosyltransferase activity
ceramide glucosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
protein localization to paranode region of axon
lipid metabolic process
sphingolipid metabolic process
cytoskeleton organization
metabolic process
glycolipid biosynthetic process
flavonoid biosynthetic process
paranodal junction assembly
cellular response to hormone stimulus
myelination
neuron projection morphogenesis
flavonoid glucuronidation
galactosylceramide biosynthetic process
glycosphingolipid metabolic process
central nervous system development
peripheral nervous system development
glycosphingolipid biosynthetic process
axo-dendritic transport
