Bioss

UHRF1/2 Polyclonal Antibody

Name: UHRF1\/2 Polyclonal Antibody
Brand: Bioss
SKU: BS-6427R

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

BS-6427R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

免疫组化（石蜡） (IHC (P))

1:200

免疫组化（冰冻） (IHC (F))

1:100-1:500

免疫细胞化学 (ICC/IF)

1:50-1:200

流式细胞分析 (Flow)

1:20-1:100

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human UHRF1.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability. Tissue specificity: Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. UHRF2 is an E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: E3 ubiquitin-protein ligase UHRF1; E3 ubiquitin-protein ligase UHRF2; hUHRF1; HuNp95; Inverted CCAAT box-binding protein of 90 kDa; liver regeneration-related protein LRRG126; mUhrf1; NIRF; Np95-like RING finger protein; Np95/ICBP90-like RING finger protein; nuclear phosphoprotein 95; Nuclear protein 95; Nuclear protein 97; Nuclear zinc finger protein Np95; Nuclear zinc finger protein Np97; RING finger protein 106; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF1; RING-type E3 ubiquitin transferase UHRF2; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like with PHD and ring finger domains 1; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin-like, containing PHD and RING finger domains 2; ubiquitin-like, containing PHD and RING finger domains, 1; ubiquitin-like, containing PHD and RING finger domains, 2; Ubiquitin-like-containing PHD and RING finger domains protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 2

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基因别名: 2310065A22Rik; Ac2-121; AI426270; AL022808; AW214556; D130071B19Rik; hNP95; hUHRF1; huNp95; ICBP90; NIRF; NP95; RNF106; RNF107; TDRD22; TDRD23; UHRF1; UHRF2; URF2