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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • UHRF1 Antibodies

          Invitrogen

          UHRF1 Polyclonal Antibody

          View all (17) UHRF1 antibodies
          Datasheet
          Protocols
          Tech Support

          Cite UHRF1 Polyclonal Antibody

          Datasheet
          Protocols
          Tech Support
          • Antibody Testing Data (4)
          UHRF1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 4

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          UHRF1 Antibody (PA5-96109) in IHC (P)

          Immunohistochemistry analysis of UHRF1 in paraffin-embedded human gastric cancer. Samples were incubated with UHRF1 Polyclonal antibody (Product # PA5-96109) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Product Details

          PA5-96109

          Applications
          Tested Dilution
          Publications

          免疫印迹 (WB)

          1:500-1:2,000
          -

          免疫组化(石蜡) (IHC (P))

          1:50-1:200
          -

          免疫细胞化学 (ICC/IF)

          1:20-1:50
          -
          产品规格

          Species Reactivity

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          Immunogen

          Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human UHRF1.
          View immunogen

          Conjugate

          Unconjugated

          形式

          Liquid

          浓度

          0.57 mg/mL

          纯化类型

          Affinity Chromatography

          保存液

          PBS, pH 7.3, with 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20° C, Avoid Freeze/Thaw Cycles

          RRID

          AB_2807911

          Product Specific Information

          Immunogen sequence: MWIQVRTMDG RQTHTVDSLS RLTKVEELRR KIQELFHVEP GLQRLFYRGK QMEDGHTLFD YEVRLNDTIQ LLVRQSLVLP HSTKERDSEL SDTDSGCCLG QSESDKSSTH GEAAAETDSR PADEDMWDET ELGLYKVNEY VDARDTNMGA WFEAQVVRVT RKAPSRDEPC SSTSRPALEE DVIYHVKYDD YPENGVVQMN SRDVRARART IIKWQDLEVG QVVMLNYNPD NPKERGFWYD AEISRKRETR TARELYANVV; Positive Samples: THP-1, HeLa, SW480, MCF7; Cellular Location: Nucleus

          Target Information

          This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Ac2-121; E3 ubiquitin-protein ligase UHRF1; FLJ21925; Hnp95 Huhrf1; hUHRF1; HuNp95; Inverted CCAAT box-binding protein of 90 kDa; MGC138707; mUhrf1; nuclear phosphoprotein 95; Nuclear protein 95; Nuclear zinc finger protein Np95; RING finger protein 106; RING-type E3 ubiquitin transferase UHRF1; Transcription factor ICBP90; ub; Ubiquitin-like PHD and RING finger domain-containing protein 1; ubiquitin-like with PHD and ring finger domains 1; Ubiquitin-like-containing PHD and RING finger domains protein 1

          View more View less

          Gene Aliases: AL022808; hNP95; hUHRF1; huNp95; ICBP90; NP95; RNF106; TDRD22; UHRF1

          View more View less

          UniProt ID: (Human) Q96T88, (Mouse) Q8VDF2

          View more View less

          Entrez Gene ID: (Human) 29128, (Mouse) 18140

          View more View less

          Molecular Function: ubiquitin-protein ligase

          Function(s)
          negative regulation of transcription from RNA polymerase II promoter DNA repair transcription, DNA-templated cell cycle cell proliferation maintenance of DNA methylation histone monoubiquitination histone ubiquitination positive regulation of cellular protein metabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of transcription from RNA polymerase II promoter protein autoubiquitination regulation of methylation-dependent chromatin silencing positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity regulation of transcription, DNA-templated cellular response to DNA damage stimulus chromatin modification
          Process(es)
          core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding ubiquitin-protein transferase activity protein binding zinc ion binding methyl-CpG binding ligase activity nucleosomal histone binding methylated histone binding histone binding identical protein binding hemi-methylated DNA-binding ubiquitin protein ligase activity DNA binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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