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Invitrogen
UHRF2 Polyclonal Antibody
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产品信息
PA5-110923
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EAFQLTPQQQ HLIREDCQNQ KLWDEVLSHL VEGPNFLKKL EQSFMCVCCQ ELVYQPVTTE CFHNVCK
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 96%.
靶标信息
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase UHRF2; Np95-like RING finger protein; Np95/ICBP90-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; RP11-472F14.2; Ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin-like, containing PHD and RING finger domains, 2; Ubiquitin-like-containing PHD and RING finger domains protein 2; unnamed protein product
基因别名: NIRF; RNF107; TDRD23; UHRF2; URF2
UniProt ID: (Human) Q96PU4
Entrez Gene ID: (Human) 115426
DNA binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
SUMO transferase activity
histone binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
ubiquitin protein ligase activity
histone H3K9me2/3 reader activity
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