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UHRF2 Antibody (PA5-96110) in WB
Western blot analysis of UHRF2 in mouse thymus. Samples were incubated with UHRF2 Polyclonal antibody (Product # PA5-96110) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-96110
产品规格
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
A recombinant fusion protein containing a sequence corresponding to amino acids 636-733 of mouse UHRF2.
Conjugate
Unconjugated
形式
Liquid
浓度
1.58 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2807912
Product Specific Information
Immunogen sequence: LQYPAGYPSE KEGKKTKGQS KKQGSEATKR PASDDECPGD SKVLKASDST DAVEAFQLTP QQQRLIREDC QNQKLWDEVL ASLVEGPNFL KKLEQSFM
Positive Samples: Jurkat, U-87MG, HeLa, Mouse liver, Rat thymus; Cellular Location: Nucleus
Target Information
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase UHRF2; NIRF; Np95-like RING finger protein; Np95/ICBP90-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; RP11-472F14.2; Ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin-like, containing PHD and RING finger domains 2; ubiquitin-like, containing PHD and RING finger domains, 2; Ubiquitin-like-containing PHD and RING finger domains protein 2
Gene Aliases: 2310065A22Rik; AI426270; AW214556; D130071B19Rik; NIRF; RNF107; TDRD23; UHRF2; URF2
UniProt ID: (Human) Q96PU4, (Mouse) Q7TMI3
Entrez Gene ID: (Human) 115426, (Rat) 309331, (Mouse) 109113
Molecular Function:
ubiquitin-protein ligase
cell cycle
cell proliferation
maintenance of DNA methylation
protein ubiquitination
cell differentiation
regulation of cell cycle
protein autoubiquitination
positive regulation of cell cycle arrest
regulation of methylation-dependent chromatin silencing
ubiquitin-dependent protein catabolic process
biological_process
DNA binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
histone binding
ubiquitin protein ligase activity
molecular_function
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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