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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • UHRF2 Antibodies

          Invitrogen

          UHRF2 Polyclonal Antibody

          View all (10) UHRF2 antibodies
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          Cite UHRF2 Polyclonal Antibody

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          • Antibody Testing Data (1)
          UHRF2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          UHRF2 Antibody (PA5-96110) in WB

          Western blot analysis of UHRF2 in mouse thymus. Samples were incubated with UHRF2 Polyclonal antibody (Product # PA5-96110) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Product Details

          PA5-96110

          Applications
          Tested Dilution
          Publications

          免疫印迹 (WB)

          1:500-1:2,000
          -
          产品规格

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          Immunogen

          A recombinant fusion protein containing a sequence corresponding to amino acids 636-733 of mouse UHRF2.

          Conjugate

          Unconjugated

          形式

          Liquid

          浓度

          1.58 mg/mL

          纯化类型

          Affinity Chromatography

          保存液

          PBS, pH 7.3, with 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20° C, Avoid Freeze/Thaw Cycles

          RRID

          AB_2807912

          Product Specific Information

          Immunogen sequence: LQYPAGYPSE KEGKKTKGQS KKQGSEATKR PASDDECPGD SKVLKASDST DAVEAFQLTP QQQRLIREDC QNQKLWDEVL ASLVEGPNFL KKLEQSFM

          Positive Samples: Jurkat, U-87MG, HeLa, Mouse liver, Rat thymus; Cellular Location: Nucleus

          Target Information

          This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: E3 ubiquitin-protein ligase UHRF2; NIRF; Np95-like RING finger protein; Np95/ICBP90-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; RP11-472F14.2; Ubiquitin-like PHD and RING finger domain-containing protein 2; ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase; ubiquitin-like, containing PHD and RING finger domains 2; ubiquitin-like, containing PHD and RING finger domains, 2; Ubiquitin-like-containing PHD and RING finger domains protein 2

          View more View less

          Gene Aliases: 2310065A22Rik; AI426270; AW214556; D130071B19Rik; NIRF; RNF107; TDRD23; UHRF2; URF2

          View more View less

          UniProt ID: (Human) Q96PU4, (Mouse) Q7TMI3

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          Entrez Gene ID: (Human) 115426, (Rat) 309331, (Mouse) 109113

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          Molecular Function: ubiquitin-protein ligase

          Function(s)
          cell cycle cell proliferation maintenance of DNA methylation protein ubiquitination cell differentiation regulation of cell cycle protein autoubiquitination positive regulation of cell cycle arrest regulation of methylation-dependent chromatin silencing ubiquitin-dependent protein catabolic process biological_process
          Process(es)
          DNA binding ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity histone binding ubiquitin protein ligase activity molecular_function UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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